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These multi-omics insights are paralleled by the development of novel therapeutic agents targeting inflammation, fibrosis, and metabolic pathways beyond traditional targets

Sections were incubated with antibodies against PCNA (PC10) (cell signaling, 12 000) and IGF-1R (N-20) (Santa Cruz, 150)

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Elevated levels of 4-HNE have been detected in several samples, including skin biopsies, various epidermal cell types, immune cells, and plasma [39,40,41,42]