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B12 supplementation is common among GLP-1 users, and many compounded formulations now include B12 in the blend or tirzepatide with B12

hsCRP, a marker of systemic inflammation that tirzepatide consistently reduces, correlates with depressive symptom severity in multiple studies

Secher said that to their surprise, her team has found that nonlipidated molecules penetrate the same way or show up in the same areas as lipidated molecules