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Free Radic Res Commun 3:3338

Microcytic anemia (low MCV, typically below 80 fL) most commonly indicates iron deficiency, thalassemia, or anemia of chronic disease

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Impaired BBB integrity Postmortem studies of AD patients and animal models have revealed cellular infiltration, including red blood cells [139], macrophages [140], and neutrophils [141], as well as capillary leakage of blood-derived components such as fibrin(ogen), IgG, albumin, thrombin, and hemosiderin [142,143,144,145]

This leads to mitochondrial dysfunction and subsequently impedes IGFs synthesis

Biotin participates in keratin synthesis