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doi:10.1038/bjp.2008.181 183

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SARS-Cov-2 virus infection may initiate a strong inflammatory and dysregulated reaction in the lung with increased levels of IL-6 and a cytokine-storm (129) which has been shown to provoke either an asymptomatic, mild, or severe infections This cytokine dysregulation may be associated with neutrophil extracellular traps (130) and alterations in T cell activity (131)

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It is also involved in cholesterol levels.[ref] Genetic variants in the methylation pathway, including MTHFR, are strongly linked to high homocysteine levels and heart disease in many studies

Recent single-cell RNA profiling of human dermal cells has revealed that restoring HES1 expression plays a pivotal role in protecting HDFs from aging-related damage 12