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Whilst transdermal patch formulations represent an area of ongoing pharmaceutical research, no GLP-1 patches are currently licensed by the Medicines and Healthcare products Regulatory Agency (MHRA) or approved by the National Institute for Health and Care Excellence (NICE) for use in the United Kingdom

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2 Introduction/background: history of incretin mimetics medications GIP was the first incretin isolated and characterized in the 1970s though most modern therapies focus on GLP-1 [17]

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Its approval was preceded by the outcomes of five phase III trials, which are summarized in Tables 1 and 2, each of which compare tirzepatide at 5 mg, 10 mg, and 15 mg to other medications comparing similar clinical endpoints

The central case after price cuts and a modest volume response translates to about $36.5 billion