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Bmal1 fx/fx ) mice (n = 6)

However, it is critical to emphasize that all current evidence comes from in-vitro and animal studies human clinical data is not yet available

While the semaglutide CVOTs did not show an increased incidence of hospitalization for HF compared to placebo (101), in earlier smaller studies with liraglutide in patients with HF with reduced left ventricular ejection fraction, the GLP-1RA was associated with increased incidence of serious cardiac events (rhythm disorders, worsening of HF) (102, 103)

This can lower inflammation and improve tissue health

doi: 10.1021/ci600404q

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