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Warnings Acetyl-L-carnitine was reported to increase chemotherapy-induced peripheral neuropathy in breast-cancer patients undergoing taxane-based chemotherapy, however the underlying mechanism was not clear (Hershman 2018)

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It is commonly investigated in preclinical research models relating to metabolic signalling pathways, cellular energy regulation, and enzymatic activity associated with nicotinamide N-methyltransferase (NNMT) interaction studies

The injury repair or chronic inflammation phase (phase III) occurs days, months, and years after HI insult