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Nature 434 , 113118 (2005)

In a headtohead trial, people taking tirzepatide lost about 20% of body weight compared with about 14% for semaglutide at 72 weeks, as reported in this tirzepatide vs semaglutide clinical comparison

organotypic hippocampal slice cultures that maintain an environment representative of an intact hippocampus were employed and evaluated for treatment-induced spinogenesis

Another potential advantage: steady-state pharmacokinetics may improve tolerability and efficacy