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All documented observations remain confined to investigational, laboratory-based examination and do not extend beyond structured research frameworks

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2.7b The Effect of Hydrocarbon Groups on Solubility The types of functional groups present in a molecule have a direct effect on its solubility in various solvents, because the functional groups determine the kinds of intermolecular interactions that are available to the molecule

Krimpenfort P, Berns A (March 2017)

This often occurs in smokers, people with metabolic disease, heavy alcohol drinkers, as a side effect of certain prescription drugs, rheumatoid arthritis and impaired thyroid function