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While using glutathione supplements can potentially cause side effects, several steps can help reduce your risk

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Pickart and Margolina's 2018 review catalogued over 4,000 human genes reportedly modulated by GHK-Cu exposure, including upregulation of collagen synthesis genes (COL1A1, COL4A1), matrix metalloproteinase regulators, and antioxidant enzymes [11]

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It just makes the process miserable and increases the risk of discontinuation