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Ursolic acid attenuates oxidative stress in nigrostriatal tissue and improves neurobehavioral activity in MPTP-induced parkinsonian mouse model

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Mechanistically, it activates the Nrf2 cytoprotective system by promoting Keap1 degradation via Atg7-dependent autophagy, disrupting the Keap1-Nrf2 interaction and enhancing Nrf2 nuclear translocation (260)