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The exact pathways for its skin-lightening effects are not fully understood but may involve inhibition of melanin synthesis

In preclinical heart failure models, NNMT enzyme inhibition markedly reduced cardiac 1-MNA (by 77.1%), improved cardiac function, reduced left ventricular hypertrophy and fibrosis, and decreased pro-inflammatory gene expression

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Am.J Med Genet

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I remember a specific case of a young man who came to me with chronic asthma but also had recurrent oral thrush (Candida on the tongue) and fungus in his toenails