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Local and systemic insulin resistance resulting from hepatic activation of IKK- and NF-B
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A single weekly injection maintains elevated GLP-1 activity for days rather than minutes
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Moreover, GLP-1 has a direct impact on pancreatic -cells within the islets of Langerhans, stimulating insulin secretion and reducing glucagon release, which collectively helps to maintain glucose homeostasis and protect against postprandial hyperglycemia [44,45]
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