is supported by the NIHR Leicester BRC and has received funding from Astra Zeneca for an investigator-initiated project
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Jones said his future research will focus on evaluating GLP-1 therapies in other high-risk gastrointestinal cancers and on designing long-term prospective studies to determine whether these medications could one day play a role in primary cancer prevention
The most recent Phase 3 trial showed discontinuation rates of 12-18% due to adverse events, higher than existing GLP-1 medications
This is why maintaining hydration and monitoring kidney function regularly is essential when using GLP-1 therapy
Abbreviations aHR: Adjusted hazard ratio BMI: Body mass index CI: Confidence interval DPP-4i: Dipeptidyl peptidase-4 inhibitor HCC: Hepatocellular carcinoma HER: Electronic health record GLP-1RA: Glucagon-like peptide-1 receptor agonist HCO: Healthcare organization ICD-10-CM: International classification of diseases, tenth revision, clinical modification ICD-10-PCS: International classification of diseases, tenth revision, procedure coding system MALO: Major adverse liver outcome MASLD: Metabolic dysfunction-associated steatotic liver disease NAFLD: Nonalcoholic fatty liver disease NASH: Nonalcoholic steatohepatitis PSM: Propensity score matching SD: Standard deviation SGLT2i: Sodiumglucose cotransporter-2 inhibitor T2D: Type 2 diabetes TZD: Thiazolidinedione References Yu M, Zhao S, Fan X, Lv Y, Xiang L, Li R
