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In addition, there is an established tolerable upper limit for nutrients that have Daily Values

In sum, the safety observations support the concept that the IRR, the target of ARA 290, is induced only by injury, inflammation or metabolic stress and is therefore not generally expressed by normal tissues, thus limiting systemic adverse events

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Selenium: This mineral is a co-factor for an enzyme called glutathione peroxidase

Interestingly, some mutant enzymes regain conformational stability in the presence of high cofactor levels, making riboflavin a viable functional rescue strategy