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However, due to a limited number of studies for some protocols, separate analyses were only feasible for examining the effects of MICT on total ghrelin in both RCTs and non-RCTs, as well as on acylated ghrelin in RCTs, and for CR interventions across all hormones in non-RCTs

The nutritional composition of meals impacts glucose and insulin dynamics, depending on the glycemic index, which influences the glycemic peak and insulin secretion [17, 18, 40,41,42]

the right window for intervention may be earlier than symptomatic disease, and a single mechanism may simply be insufficient against a process with many drivers