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10.18632/oncotarget.18895 307 ZhouJ.YangZ.ShenR.ZhongW.ZhengH.ChenZ.et al (2021a)

The Effectiveness of Intermittent Fasting to Reduce Body Mass Index and Glucose Metabolism: A Systematic Review and Meta-Analysis

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In a chronic restraint stress (CRS) model, ER stress is activated through the PERK pathway, upregulating phosphorylated eukaryotic initiation factor 2 (P-eIF2) and CCAAT/enhancer binding protein (C/EBP) homologous protein expression, leading to damage of the jejunal and colonic mucosa and disruption of barrier function [85]