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Evolutionary pressures clearly differ between the core C-terminal region, which shows rapid sequence evolution but retains structural homology across Buchnera and beyond, and the N-terminal region, which retains little recognizable homology in structure or sequence
doi: 10.1007/s12035-014-8705-x
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Both drugs are made by Novo Nordisk
However, the reduced appetite can sometimes be extreme, causing patients to feel uninterested in eating, which can lead to reduced energy levels or even malnutrition if not managed properly