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When people stop taking semaglutide or tirzepatide, appetite hormones like ghrelin rebound, hunger signals return to baseline levels, and the metabolic advantage from the drug disappears within weeks

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The agency has flagged it among bulk substances it sees as safety risks for compounding, and its status is shifting: a federal compounding advisory review is set for July 2026 to weigh whether licensed pharmacies can prepare it

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We herein review perturbations in purine and neurotransmitter metabolism observed in early SZ using a metabolomic approach