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Similar to the therapeutic approach of GLP-1RA in T1D demonstrated in multiple clinical trials (169171), microvascular protection might also be achieved with SGLT-2 inhibitors, with some trials aiming to minimize the risk of ketosis (172), such as by using glucagon (GCG) inhibitors (173176), as research has shown specific benefits that could be derived from this, independent of the different pathophysiology of microvascular complications in T2DM (177)

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