Although GLP-1 receptor agonists have demonstrated effectiveness in reducing weight loss and risks for other chronic diseases, questions remain over whether the benefits outweigh the harms of the drugs, including their cost-effectiveness and economic impact, Hannah Moll, a PhD candidate from the department of epidemiology at the University of Zurich in Switzerland, and colleagues, wrote in eClinicalMedicine
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Uncertainty about long-term follow-up
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With a mean follow-up of 2.6 years, the study demonstrated a 34% reduction in the relative risk (RR) of a composite renal outcome, including dialysis requirement, a decline in glomerular filtration rate (GFR) 7% were initiated on the complementary drug to complete the GLP-1 RA + SGLT-2i combination therapy