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Furthermore, a deficiency in Zip7 shifts macrophage activation towards an M2 phenotype, as evidenced by increased expression of the M2 marker CD206 and reduced levels of the M1 marker NOS2, along with lower production of proinflammatory cytokines such as TNF- and IL-6

The side effects aren't the limiting factor

it increases insulin secretion from the pancreas, helping regulate blood sugar

An open-label oral semaglutide arm was included for exploratory comparison

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