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291 , 1299113004 (2016) Moon, M

Glutamine has a versatile role in cell metabolism, participating in tricarboxylic acid (TCA) cycle supplementation and the biosynthesis of nucleotides, glutathione (GSH), and other nonessential amino acids

Imbalances can result in loss of energy, increased irritability, sleeplessness, memory problems, and low sex drive

And we know theres bone loss that accompanies weight loss with these medications

In addition, we previously showed that upon inhibition of glutamine, cancer cells reduce the amount of GSH by exporting oxidized glutathione (GSSG) out of the cell via GSSG transporters and multiple-drug resistance-associated proteins 57 and by extracellular degradation of GSSG 58

Cys-Gly is further split by dipeptidases into cysteine and glycine for cellular reuptake and regeneration of new GSH