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Most compounds that target tumor metabolism (methotrexate, 5-fluorouracil) fail to distinguish between tumor tissue and rapidly differentiating epithelial tissue (skin, bone marrow), 4,322 whereas therapies targeting the specific amino acid dependence of tumor cells are cell-selective, such as leukemic blasts that are selectively dependent on Asn, the use of bacterial-derived ASNase in pediatric ALL has significantly improved the cure rate
Not to be used for the diagnosis, treatment, cure, or prevention of any disease
Nillert N, Pannangrong W, Welbat JU, Chaijaroonkhanarak W, Sripanidkulchai K, et al
doi: 10.1056/NEJM200011233432103 18 GautamRSinghMGautamSRawatJKSarafSAKaithwasG
MOTs-C enhances energy production and improves metabolic function
10.1111/jpi.12210 49 HossainM
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