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Adverse effects include muscarinic symptoms (e.g., gastrointestinal upset, increased secretions) and nicotinic effects (e.g., muscle cramps, fasciculations, weakness)

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Allelic loss of the NF1 gene in NF1-associated plexiform neurofibromas

For comparison, the catalytic triad in enzymes like chymotrypsin, another well-known serine protease, comprises Histidine (His), Aspartic acid (Asp), and Serine (Ser)

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