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Rare but serious risks include pancreatitis and gallbladder disease with GLP-1 agents, and lactic acidosis with metformin in renal impairment or acute illness

doi: 10.3390/ph15020176 48

When smoked or otherwise consumed, cannabis affects the central nervous system, producing effects ranging from relaxation and altered perception to increased appetite (often termed "the munchies"), changes in mood, and impaired cognitive function

Exendin-4, a GLP-1R agonist, also suppressed basal expression of several inflammatory mediators and in combination with phosphodiesterase inhibitors, decreased CXCL10 expression by IFN- (a type II-interferon) in human islets and in MIN6 cells (a mouse -cell line)

You start to feel inward signs, like fatigue, mood swings, and low sex drive

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