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While the mechanistic insights are encouraging, further clinical investigations are needed to isolate the direct analgesic effects of GLP-1R agonists from those mediated by weight loss
However, due to its invasiveness, it should be offered preferentially to patients with exhausted non-pharmacological and pharmacological treatment options
Br J Clin Pharmacol (2019) 85:271420
Among adults who have used these drugs, seven in ten say they used them primarily to treat a chronic condition like diabetes or heart disease (38%) or to both treat a chronic condition and lose weight (32%), while three in ten GLP-1 users (30%) report using these drugs primarily to lose weight
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