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In a patient with normal B12 status, injecting more of it does not create surplus energy or burn fat

Conditions that can cause cobalamin deficiency include: Inflammatory bowel disease (IBD) Exocrine pancreatic insufficiency (EPI) Pancreatic cancer Chronic enteropathy Alimentary lymphoma Small intestinal dysbiosis Inherited selective cobalamin malabsorption Inherited selective cobalamin malabsorption, which is known as Imerslund-Grsbeck syndrome (IGS) in humans, makes a dog genetically predisposed to have difficulty absorbing cobalamin

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This often leads to painful and/or disruptive symptoms in the feet and lower legs but these symptoms may also progress to other parts of the body

To explore AdoCbls therapeutic potential, the team next administrated it in worms carrying the G2019S mutation