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But hundreds of examples in one country is far from a preponderance of evidence

Elevated pro-inflammatory cytokines such as TNF-, IL-1, and IL-6 can cross the BBB, activating microglia and amplifying neuroinflammation (118)

This allows toxic microbial metabolites and other harmful substances to enter systemic circulation, activating the immune system and promoting the release of pro-inflammatory cytokines

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In response, Congress and the FDA had strengthened oversight

Heavy-drinking days are defined by NIAAA as four or more drinks for women, five or more for men in a single occasion