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Theyve spent all this money on treatment, and suddenly the weight has come back on. Lastly, some patients have mentioned an impact on impulsive behaviours when the dopamine regulation effects of GLP-1 agonists appear to wear off

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Why Titration Length Affects the Outcome Numbers Because retatrutide patients spend 24 weeks reaching maintenance dose while Saxenda patients spend 5 weeks, any per-protocol weight-loss comparison at, say, week 12 will underestimate retatrutide's ceiling effect