Glycosuria contributes directly to improved glycemic control, while increased distal sodium delivery restores normal tubuloglomerular feedback, thereby lowering intraglomerular pressure, which is a key mechanism in slowing DKD progression [25,27]
It has the same proposed mechanism: turning fiber into butyrate to support natural GLP-1 production
However, tirzepatide has a longer track record and more extensive safety data
We offer daily oral tablets of semaglutide and tirzepatide if youre adverse to needles
I enjoyed contributing to this blog post at Smith Performance Center with Craig Smith, where we discuss protein intake and practical ways to individualize recommendations
The main adverse effects in the semaglutide arm were gastrointestinal (GI) related, which included nausea, vomiting, diarrhea and constipation