Retatrutide , a newer triple receptor agonist, shows similar GI side effect patterns in clinical trials
[Abstract]2022 Aug 10;96(15):e0078622
Stop and Seek Help If Any severe hypoglycemic episode that doesn't resolve quickly with food Persistent numbness, tingling, or carpal tunnel symptoms Joint pain that interferes with training or daily activities Signs of allergic reaction (rash, swelling, difficulty breathing) Any concerning or unusual symptoms that worry you Completion of your planned cycle (typically 4-6 weeks) IGF-1 LR3 is a research compound, not approved for human therapeutic use by the FDA
PMCID: PMC8478295
When to Contact Your Doctor About GLP-1 Digestive Side Effects Reach out to your healthcare provider if diarrhea is severe, bloody, accompanied by fever or severe abdominal pain, or lasts longer than 8 weeks
Experimental data indicate that GPER-specific agonists, exemplified by G1, increase the expression of mineralization markers in osteoblasts, thereby promoting bone formation [111]