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In animal models, high-dose ketamine (100 mg/kg daily) caused mitochondrial swelling, DNA damage, and ATP production deficits (Huang et al., 2024)

The following solutions were mixed together: 100 L of cells in TE buffer, 10 L of herring sperm DNA (10 mg mL 1 ), 10 L of SAT1 flipper disruption cassette (0.1 g L 1 ), and 5 L of histamine solution (Qbiogene)