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DISCUSSION Psoriasis is a complex autoimmune disease resulting in significant morbidity and early mortality compared to the general population.1 Psoriasis patients are known to have abnormal GSH enzyme activities and high levels of free radicals.3,4,22 This increase in oxidative stress can be measured systemically2,23 and affect other tissues

It exists as a 32 kDa homodimer, mainly confined to the cytoplasm, with a smaller proportion in the mitochondrial intermembrane space (IMS)

Baltaci, Davut, et al

It depends on selenium to function effectively

It is particularly beneficial in animals suffering from stress, chronic illness or poor appetite

In the context of pyroptosis, ROS play roles in the activation of the NLRP3 inflammasome and caspases (Fig