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Gangadoo et al

NAC-treated mice also showed a rapid response to insulin administration (Fig

Similar levels of urinary carnitine excretion in the 2 genotypes (Figure 6G) and reduction in fractional excretion of carnitine in cKOt mice (FE, Figure 6H) indicated that a reduction in plasma carnitine levels occurred in parallel with decreased carnitine reabsorption in the kidney

Specifically, it showed that chronic, excessive alcohol consumption leads to a reduction in dopamine release in the NAc, and that the activation of GDNF signalling in the VTA reduces alcohol consumption by normalizing dopamine levels in the NAc