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[DOI] [PubMed] [Google Scholar] 25.Radi R, Peluffo G, Alvarez MN, Naviliat M, Cayota A

This is particularly relevant given that mast cells are also located near neurons, glia, and cerebral blood vessels 20

Ilyas Z, Perna S, Al-Thawadi S, Alalwan TA, Riva A, Petrangolini G, et al

Lancet 402:529544

And in the brain, it crosses the blood-brain barrier and activates anorexigenic neurons in the hypothalamus, specifically the POMC/CART pathways that signal fullness while suppressing the NPY/AgRP pathways that drive hunger

Semaglutide GLP-1 can help patients achieve weight loss by reducing appetite, creating a feeling of fullness, and improving insulin sensitivity