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Subsequently, LDL promoted the proliferation and invasion of TC cells [101]

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Of note, in agreement with their mechanisms of action, cell treatments with 354 and VX-497 caused opposite effects in steady state levels of IMPDH2: whereas 354 decreased or totally depleted IMPDH2, VX-497 caused a dose-dependent increase of IMPDH2 levels, by a feedback response of the purine synthesis pathway 49,50,51 (Fig