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Native rhIGF-1 (mecasermin, brand name Increlex) is FDA-approved only for the long-term treatment of growth failure in pediatric patients with severe primary IGF-1 deficiency or with GH gene deletion who have developed neutralizing antibodies to GH

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doi:10.1128/AAC.00414-16 87

Any use in humans or animals is strictly prohibited and may violate federal, state, or local laws, including the Federal Food, Drug, and Cosmetic Act

Nails grow faster and may feel stronger, a secondary indicator of systemic collagen metabolism improvement

Its mechanism centers on copper-dependent signaling that modulates gene expression across multiple tissue-repair pathways