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Sasaki, M., Miyakoshi, M., Sato, Y

Inhibition of the IGF signaling pathway reverses cisplatin resistance in ovarian cancer cells

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Simultaneously, hydrogen selenide (H 2 Se) generated from the metabolism of dietary selenium species is converted into selenophosphate (H 2 SePO 3 ) by the enzyme selenophosphate synthetase 2 (SEPHS2) which is then used as a substrate by the enzyme O-phosphoseryl-tRNA [Ser]Sec selenium transferase to incorporate selenium into phosphoseryl-tRNA [Ser]Sec to form Sec-tRNA [ser]sec

We also outline current studies that support the involvement of the gut microbiota and mesenchymal cells in the development and progression of UC, with implications for therapeutic development