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What they're saying: "As the accessibility of these medications continues to rise and patient uptake increases, its crucial that we understand the neural mechanisms underlying the effects were seeing," Lorenzo Leggio, the clinical director of NIHs National Institute on Drug Abuse, said in a statement

Anderson, MD, MAS, an assistant professor of medicine at the University of Pittsburgh, and Deborah Grady, MD, MPH, a professor emeritus of medicine and of epidemiology and biostatistics at the University of California, San Francisco, reiterated that the findings are reassuring and support preliminary data from the FDA and European Medicines Agency, but the results do not answer definitely whether or not this drug class poses safety concerns regarding mental health

This medication is not appropriate for individuals with a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2), or those who are pregnant or breastfeeding

mode of dialysis & when to discontinue Intermittent hemodialysis is preferred to maximize removal of valproic acid

The earlier you recognize these signals, the easier the course correction

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