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A preprint study (meaning it has not yet been peer-reviewed for publication in a medical journal) found that women taking semaglutide (Wegovy) or tirzepatide (Zepbound) had a 2.5-fold higher rate of nausea and vomiting compared with men

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The neurons in these areas that express the GLP-1 receptor interact with GLP-1 analogs, indirectly influencing central circuits

Clinical guidance suggests starting with manufacturer recommendations as outlined in FDA labeling, then adjusting based on individual response

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Some of the drugs mentioned are investigational and have not been approved by the FDA or other regulatory agencies for the uses discussed.