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The concept of 'cycling'alternating periods of use ('on-cycle') with periods of non-use ('off-cycle')is a cornerstone of responsible research

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10.1042/BST20120331 [DOI] [PubMed] [Google Scholar] Kenakin T

The results showed a decrease in COX-2 expression in all groups given the 1.3 bis( p -Hydroxyphenyl)urea and sodium diclofenac compared to the control group CMC sodium 0.5%

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A hydrogel system with continuous delivery of bFGF was prepared with a significant effect on wound healing in aged rats (Xiao et al., 2022)