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First, the glutamate cysteine ligase (GCL) catalyzes the formation of a dipeptide constituted by glutamate and cysteine, and then the GSH synthetase catalyzes the addition of glycine to form GSH[38], the former being the rate-limiting step

Metformin treatment significantly reduced the percentage of live HCT116 and SW837 cells following irradiation with 1.8 Gy, when compared to irradiated vehicle controls ( Figure 3A )

"Vitamin D: an innate antiviral agent suppressing hepatitis C virus in human hepatocytes"

These findings provide direct evidence that gut-driven KP dysregulation is sufficient to induce affective phenotypes, independent of genetic or psychosocial factors

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