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The first is that semaglutide is semaglutide the molecule that produced about 15% mean weight loss in STEP 1 (Wilding et al., 2021), that reduced food-cue reward signalling in van Bloemendaal's imaging (van Bloemendaal et al., 2014), that the broader incretin literature has characterised in detail (Drucker, 2018), does not become a different molecule because of where it was synthesised

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[39] revealed that the phosphorylation of STAT3 by JAK1 was prevented by SOCS1 protein