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While this is protective against age-related hyperfunction, it theoretically risks blunting the anabolic responses required for new synaptic formation, muscle hypertrophy, or exercise adaptation in subjects who are not already biologically aged

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Smoking, alcohol, lack of sleep, and processed foods rapidly deplete glutathione levels

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Chronic inflammation is also associated with metabolic disorders, such as non-alcoholic steatohepatitis (NASH) caused by hepatic lipid accumulation, and high-fat diet induced glucose intolerance