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Most individuals begin to see more substantial results after three to six months of consistent therapy

It may thus be suggested that direct exposure of the gut to the microbiome - capable of synthesizing thiamine antagonists or possessing thiamine-degrading thiaminase II - may first of all affect the gut, leading to gastrointestinal beriberi, especially under conditions of SIBO or other disturbances of the gut microbiome

Melanotan (MT)-II significantly enhances the recovery of sensory function following a crush lesion of the sciatic nerve in the rat at a dose of 20 g/kg per 48 h, s.c., but not at a dose of 2 or 50 g/kg[3]

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Body composition changes tend to follow over the subsequent months as growth hormone levels stabilise