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Use of IL-23-targeting therapies is highly effective, with sustained disease control over time

However, the absence of documented cases does not definitively exclude the possibility of an association, particularly given the relatively recent widespread use of semaglutide

Some researchers explore peptide stacking strategies that combine GH secretagogues with GLP-1 agonists, though evidence for these combinations comes primarily from anecdotal reports rather than controlled trials

In the 2025 SURMOUNT-5 trial, adults with obesity but without diabetes received tirzepatide or semaglutide once weekly for 72 weeks

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