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1,2 Effective post-overdose interventions remain limited: medications for opioid use disorder reduce repeat overdose risk substantially but reach only a small minority of survivors, and no widely used pharmacotherapy addresses the broader range of substances involved in overdose events

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We previously reported that La 3+ and Ruthenium Red, non-selective TRP channel blockers, strongly inhibited triagonist-enhanced GSIS and significantly suppressed triagonist-induced Ca 2+ influx in 1.1B4 cells [9]

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