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Supplementary material The Supplementary material for this article can be found online at: References 1 Abd El-HadyA

The suggested peptide, which has the sequence RER-EtBn, has the ability to stimulate the phosphorylation of its major target, AKT serine, inhibit the phosphorylation of Gsk-3, and then promote the translocation of the GLUT4 protein to the cell membranes surface to promote glucose translocation, all of which have a positive impact on the state of insulin-resistant glucose metabolism (53)

These components support sustained cell proliferation, enhance survival signals to prevent apoptosis, and promote angiogenesis

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