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According to Abarikwu et al

However, while glucagon receptor antagonism was considered a popular mechanism for the treatment of T2D a few year ago, adverse effects have refocused the therapeutic approach toward glucagon receptor agonism

SFB is also involved in the promotion of maturation of T-regulatory cells (T-reg) They perform a mutualistic interaction with the intestinal microbiota by secreting anti-inflammatory cytokines, such as IL-10 and Transforming Growth Factor - (TGF-)

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